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ELS215: The Progression of Potts Disease

Several pathologies in the skeleton show that ELS215 suffered from advanced Pott’s disease (also known as tuberculous spondylitis), a form of tuberculosis that spreads from the lungs to the spine via the bloodstream. As a result of this infection, nine of ELS215’s vertebrae collapsed and fused (six thoracic and three lumbar vertebrae), resulting in a permanent curvature (kyphosis) of over 90 degrees. Her ribs and her pelvis also show signs of the disease in their rough, irregular surfaces. 

 

The symptoms of Pott’s disease include fever, back and neck pain, arm and leg weakness, unexplained weight loss, lack of appetite, and issues with coordination or muscle control. 

 

CT scans conducted at the Clinical Research Centre at Ninewells Hospital show Pott’s disease caused ELS215’s spinal column to collapse, resulting in paralysis. The scans also show that she lived long enough after this collapse for bone inside the spinal column to remodel, a process in which mature bone tissue is removed from the skeleton and new bone tissue is formed. During this time, ELS215 would have lost control of her bowels and bladder, and would have needed help with all basic functions such as eating, bathing, and movement. 

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